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    Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland ... Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland ...
    Published online 2016 Nov 4. doi: 10.3390/toxins8110275 .... Pueraria mirifica ( PM), a plant whose dried and powdered tuberous roots are now ... Until now, no serious side effects have been recorded with the ... (C–L) female Donryu rats administered Pueraria mirifica (PM) and isoflavone aglycon (IA) for the first 4 days.

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    Pm on mammary gland and uterus were comparable with those of 0. It can be readily obtained from internet resources in many countries, including the usa and japan, and is primarily used for supporting memory, smoothing the skin, increasing hair growth, improving appetite, and providing relief for ailments like osteoporosis and even cancer. The dunnetts multiple comparison test (two-sided) was used in case of homogeneous data, otherwise the steels test (two-sided) was applied this work was supported by a grant-in-aid for scientific research from the ministry of health, labor and welfare of japan.

    A new decision tree method for statistical analysis of quantitative data obtained in toxicity studies on rodent. The absence of dose-dependence in the effects of pm on mammary adenocarcinomas may be related to side effects exerted at high doses, with best incorporation of its ingredients reaching working physiological intracellular concentrations at a dose of 0. At the commencement of the experiment, 5-week-old rats from pm-treated, ia-treated, and initiation control groups (21 ratsgroup) were given a single dose of dmba by i.

    In case of bsa normalization, pm doses of 20, 200, and 2000 mgkg b. Nowadays, doses of 20100 mgday are commonly used, but in some cases 200900 mgday or even higher (up to 3000 mgday) are applied. Vaginal smears were obtained daily before and after starting the treatment, dried and stained with an aqueous solution of methylene blue.

    Trophic effects of estrogenic compounds on the mammary gland and uterus were previously suggested to be due to activation of signaling through estrogen receptors (ers) er and er. The accuracy of dose formulation and uniformity of blending of the diets was confirmed by the analytical chemistry laboratories at oriental yeast co. Animal body weights were measured once a week, and general condition was examined once a day.

    Thus, weak, medium, and strong estrogenic activities of pm at doses of 0. Ia were administered in nih-07pld diet for 4 weeks starting from the day of dmba injection. In the present experiment, test powder diets were prepared as follows 0.

    The present results demonstrated that long-term postpubertal exposure to pm at doses higher than 200 mgkg b. Atypical glands present in the endometrium proliferating irregularly and invading the muscle layer (arrows). Recently, we further demonstrated that postpubertal administration of soy isoflavones at estrogenic doses promotes mammary and endometrial carcinogenesis in donryu rats. Until now, no serious side effects have been recorded with the prescribed safe dosage, although at high doses pm may cause epilepsy, diabetes, asthma, and migraine despite the data on the benefits of pm, there are reasons for concern that a herb which exhibits strong estrogen-like properties may stimulate the growth of existing estrogen-sensitive breast or endometrial tumors, pointing out questions such as what is a safe dose? Previously, nanomolar concentrations of genistein, present in pm, was shown to induce acid ceramidase (asah1) transcription through a gpr30-dependent, pertussis toxin-sensitive pathway that requires the activation of c-src and extracellular signal regulated kinase 12 (erk12), thus stimulating breast cancer cell growth. All animals were checked once daily for general behavior and signs of toxicity or a moribund state.


    Effect of Pueraria mirifica on vaginal health. - NCBI


    OBJECTIVE: To evaluate the effect of Pueraria mirifica on vaginal symptoms, ... health index, vaginal pH, and vaginal cytology in healthy postmenopausal women. ... no significant difference of adverse effects between the Pueraria mirifica and ...

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    Pueraria Mirifica Side Effects Female Viagra Buy Now Effects of reproduction on spontaneous development of endometrial adenocarcinomas and mammary tumors in donryu rats. These data are in line with recent results demonstrating that long-term treatment of aged menopausal monkeys with 1000 mgday of pm decreased serum parathyroid hormone (pth) and calcium levels in the blood likely due to the amelioration of the bone loss caused by estrogen deficiency in conclusion, in the present study long-term postpubertal treatment of donryu rats with pm at a dose of 200 mgkg b. One hundred and seventeen 5-week-old female donryu rats were divided into seven groups. Since the onset of puberty is defined as the age (in days) at which vaginal opening occurs, rats were inspected daily for this purpose. Effective number of rats significantly different from the dmba, enng control group at 0, A significant increase in the multiplicity of total atypical hyperplasias (hpls) (mild, medium, and severe) was found in 0.
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    Pm for 90 days produced a dose-dependent reduction in the urinary follicular stimulating hormone (fsh), luteinizing hormone (lh) and estradiol levels in the blood, and the single dose of 1000 mg disturbed ovarian function and menstrual cycling. Donryu rats with a mean body weight of 200 g consumed pm in 15 g diet at doses of 20 (0. Nih-07pld basal diet for 36 weeks from the commencement of the experiment. An automated hematology analyzer (sysmex xe-2100, mitsubishi chemical visuals, osaka, japan) and an automatic analyzer (olympus aj-5200, tokyo, japan) were employed for hematological and biochemical analyses of blood serum as previously described statistical analysis was performed using the statlight-2000(c) program (yukms corp. These data call into question the safety of long-term exposure to phytoestrogens with regard to effects on the mammary gland and endometrium.

    We also observed that 1 pm suppressed lymphocyte and platelet counts but elevated neutrophil levels, presumably reflecting effects on the immune system, promoting inflammation, and bone marrow suppression. Pm dose used in our experiment would be accepted as safe for humans (2 mgkg b. We have previously shown that ia at an estrogenic dose of 150 mgkg b. However, in the case of pm, there are almost no data concerning the concentration of ingredients in the blood and tissues. Data for changes in mammary gland adenocarcinoma and benign tumor incidences, multiplicities, and volumeswith representative picturesare shown in ) of initiation control, pm-, and ia-administered rats in experiment 3 (hematoxylin and eosin).

    Immunoreactivity was detected using a vectastain elite abc kit (pk-6102 vector laboratories, burlingame, ca, usa) and 3,3-diaminobenzidine hydrochloride (sigma chemical co. In blood biochemistry, significant inhibition and a trend for decrease in total cholesterol and triglyceride levels were found in pm- and ia-administered rats after initiation and in the vehicle 1 pm group. Ia-administered rats were lower than in the initiation control group, with significant differences detected at the termination of the experiment. Genistein stimulates mcf-7 breast cancer cell growth by inducing acid ceramidase (asah1) gene expression. To evaluate the effect of pueraria mirifica on vaginal symptoms, vaginal health index, vaginal ph, and vaginal cytology in healthy postmenopausal women. When pm was administered at a dose of 1 without initiation, ht and lymphocyte count were significantly suppressed but neutrophils elevated, indicating higher levels of inflammation. It can be readily obtained from internet resources in many countries, including the usa and japan, and is primarily used for supporting memory, smoothing the skin, increasing hair growth, improving appetite, and providing relief for ailments like osteoporosis and even cancer. Until now, no serious side effects have been recorded with the prescribed safe dosage, although at high doses pm may cause epilepsy, diabetes, asthma, and migraine despite the data on the benefits of pm, there are reasons for concern that a herb which exhibits strong estrogen-like properties may stimulate the growth of existing estrogen-sensitive breast or endometrial tumors, pointing out questions such as what is a safe dose? Previously, nanomolar concentrations of genistein, present in pm, was shown to induce acid ceramidase (asah1) transcription through a gpr30-dependent, pertussis toxin-sensitive pathway that requires the activation of c-src and extracellular signal regulated kinase 12 (erk12), thus stimulating breast cancer cell growth. Results of histopathological analysis demonstrated significant increase of incidence ( 0. Furthermore, pm elevated cell proliferation in the mammary glands of dmba-initiated rats, which might lead to the promotion and progression of mammary tumors to greater malignancy.

    Find patient medical information for Butea Superba on WebMD including its uses, effectiveness, side effects and safety, interactions, dosage, user ratings and ...

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